The CLARIOstar is a multimode microplate reader with advanced LVF monochromators, highly sensitive filters, and an ultra-fast UV/VIS spectrometer. It is a modular microplate reader with up to eight different detection modes: fluorescence intensity (including FRET), fluorescence polarization, luminescence (including BRET), UV/Vis absorbance, time-resolved fluorescence (including TR-FRET), and AlphaScreen/AlphaLISA